new article 2023

The research article entitled “Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium-on-chip model” has been published in the journal Artificial Cells, Nanomedicine, and Biotechnology.

The determination of the permeability of drugs, cosmetics and chemicals through tissue barriers represents a useful tool for the pharmaceutical and cosmetic industries as well as for toxicological studies.

In this work, we present a new stratified epithelium-on-chip model. This model allows to correlate the Stokes radius and the permeability coefficient of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data, we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles.

Great work, and congratulations to all the authors!