DISCOVER
TME LAB

The Tissue MicroEnvironment Laboratory (TME_Lab) is a highly multidisciplinary research group, composed of engineers, mathematicians, biologists, and researchers from other biomedical branches, whose main aim is modeling and understanding the interactions between cells and with their microenvironment in physiological and pathophysiological conditions to find new personalized therapeutic strategies

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WHO WE ARE?

TME Lab is one of the research groups of the Aragón Institute of Engineering Research (I3A) that belongs to the University of Zaragoza. It has been officially recognized as a consolidated group by the Government of Aragón. It is also member of the Health Research Institute of Aragón (IIS Aragón), and of the national Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) that belongs to the Carlos III Health Institute (ISCIII) as part of the group CB06/01/0069.

This group was created in 2011 as a continuation of the former Group of Structural Mechanics and Materials Modeling (GEMM). Today, the group is composed of 5 senior researchers, all doctors, 11 PhD students, and 2 technicians that share common objectives and research and training strategies.

We count with state-of-the-art laboratories, special contacts with two spin-off companies from the University of Zaragoza, part of whose promoters and members of their Scientific Advisory Board belongs to TME_Lab: Ebers Medical Technology S.L. and Beonchip S.L.

 

 

WHAT IS OUR AIM?

Our main aim is to develop and apply multiapproach models (in silico, in vitro, and ex vivo) to better understand relevant biological processes, with special emphasis on the interaction between cells and their biophysical environment.

We are experts in developing biological models integrating the state of the art in mathematical simulation tools and microfluidic technology to mimic biological functions or diseases and monitor cells and tissues in biomimetic environments.

We mainly focus on reproducing physiological and pathological situations to better understand biological processes with industrial or clinical impact.

 

 

ONCOLOGY 

IN VITRO MODELS

CARDIOVASCULAR 

MICROFLUIDICS MODELS

ORGAN ON CHIP

IN SILICO MODELS

WHAT WE DO?

We try to cover all facets of a research group: fundamental research, translation to clinics, and technology transfer to industry and high-level training.

Our main difference is the seamless combination in most of our projects of physico-mathematical or data-driven models with biomimetic microfluidic based devices to build reliable, robust, easy-to-use and cost effective models of relevant biological problems which could impact the clinical practice and medical industry.

We develop our research under the umbrella of national and European projects in close collaborations with other national, international groups as well as companies and clinicians.

Our outcome is related to publications in high-impact journals, patents, and products and training of new PhDs. With this aim, we are a group always open to incorporate new talents, where they will find a very proactive group involved in ambitious projects.

 

PROJECTS

PATENTS

TEACHING

TRANSFER PROJECTS

SPIN-OFF

PUBLICATIONS

NEWS

Maricke Angenent, ERASMUS Internship

In the last four months, Maricke has been working in our group. Her work was focused on developing a skin on-chip model. Her goal was to improve her experience in the laboratory, in cell culture. And we hope she not only accomplished that but she also had a great time...

3rd Sino-Spanish Research and Innovation Forum

Jacobo Ayensa presented the talk, titled: "Bio In silico models for understanding and predicting the evolution of glioblastoma tumor in vitro" during the 3rd Sino-Spanish Research and Innovation Forum. 2021 Materials and Nanotechnology Forum. About the Forum "As...

Three Minute Thesis_Jacobo Ayensa Jimenez

Following the model of the annual contest, The Three Minute Thesis or '3MT takes place in more than 200 universities around the world. This contest challenges participants to present their research in just 180 seconds, in an engaging form that can be understood by an...