Journal of Molecular Sciences_ MDPI_OpenAccess

TME lab members have published a new research article entitled “Human Dermal Decellularized ECM Hydrogels as Scaffolds for 3D In Vitro Skin Aging Models” in the journal International Journal of Molecular Sciences. This article was carried out by the members of our group, Estibaliz Fernandez-Carro, Ana Rosa Remacha, Clara Alcaine and Jesús Ciriza, in collaboration with Proteomics Research Core Facility – Instituto Aragonés de Ciencias de la Salud (IACS), Department of Anatomy and Histology, Faculty of Medicine – University of Zaragoza and Departamento de Química Orgánica-Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza.

To represent the tissue microenvironment of aged human dermis as closely as possible to reality, we obtained and characterized aged human decellularized dermal extracellular matrix (dECM) hydrogels extracted from cadaveric human skin. Our results demonstrate that dECM hydrogels preserve essential components of the native human dermis, making them a suitable option for developing 3D skin aging models that accurately represent the cellular microenvironment. This advancement improves existing in vitro skin models and allows for more reliable results in dermatopathological studies.

Great work, and congratulations to all the authors!

Check it out here