- European union - AEI - MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES
UNLOOC
Unlocking the data content of Organ-on-Chips. G.A.: 101140192
UNLOOC is a 3-year project tackling the challenge inherent in animal testing of drugs. It brings together 51 organisations from 10 European countries. The consortium aims to demonstrate through its five novel use cases how the groundbreaking methods using Organ-on-a-Chip (OOC) technology enable the development of more effective treatments, leaving animal subjects out of the equation. The OOC technology to be developed in the UNLOOC project will not only enable controlled drug testing, but also the modelling of disease pathophysiology. The project’s total budget of €68 million consists of €14 million in funding from the Chips Joint Undertaking, €3 million from Swiss State Secretariat for Education, Research and Innovation (SERI), €18 million from national agencies and €33 million from partners’ own contribution.
This project is supported by the Chips Joint Undertaking (Grant Agreement No. 101140192) and its members including the top-up funding of Belgium, Germany, Hungary, Ireland, Italy, the Netherlands, Portugal, Romania and Spain. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI).
- European union - AEI - MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES
UNLOOC
Unlocking the data content of Organ-on-Chips. G.A.: 101140192
The UNLOOC project will focus on five innovative use cases:
UC1: 3D organ models that replicate human diversity through an innovative cryopreservation method.
UC2: Development of market-ready single-organ and multi-organ OOC (Organ-on-a-Chip) multi-well plates.
UC3: Design and validation of artificial epithelia to evaluate transdermal drug delivery, skin penetration, absorption, and toxicity.
UC4:Creation of a platform integrating a blood-brain barrier model for biomedical research laboratories, scalable for research organizations.
UC5: Development of an advanced lung-on-a-chip platform to better assess the safety of new drugs.
Our group is envolved in Use case 4: BBB-on-Chip
Integrated fluidic control, sensing, and incubation system for the BBB-on-Chip: Designing a blood-brain barrier (BBB) platform that is affordable for biomedical research labs and scalable for contract research organizations (CROs).
This use case is led by BEOnChip S.L. (Spain).
